Oxytocin Hormone Administration Attenuates Cardiac Oxidative Injury and Inflammation in Hypercholesterolemic Rats

Nazmy, Walaa `Hassan and Ibrahim, Hanaa M. and Saad, Adel Hussein and Rheim, Alaa El Din R. Abdel (2016) Oxytocin Hormone Administration Attenuates Cardiac Oxidative Injury and Inflammation in Hypercholesterolemic Rats. Journal of Advances in Medical and Pharmaceutical Sciences, 10 (2). pp. 1-10. ISSN 23941111

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Abstract

Aims: Oxytocin (OT) hormone has been recently recognized as a cardiovascular hormone with diverse regulatory roles. The present study examined the potential protective effect of exogenous OT administration on hypercholesterolemia-induced injury in rat heart and possible mechanisms involved.

Methodology: Hypercholesterolemia was induced in adult male albino rats fed high cholesterol diet 2% either with or without daily subcutaneous injection of OT (1.6 µg/kg body weight/day) for 8 weeks. Serum parameters included; Serum lipid profile, C-reactive protein, cardiac injury markers including lactate dehydrogenase (LDH) and creatine kinase (CK) levels were measured. Cardiac tissue parameters included malondialdehyde (MDA), total anti-oxidant capacity (TAC), nitric oxide (NO) and tumor necrosis factor-α (TNF-α) contents.

Results: Hypercholesterolemic rats showed marked dyslipidemia, significantly high serum levels of C-reactive protein, LDH and CK. Cardiac tissue samples showed enhanced oxidative stress and inflammation in terms of increased MDA and TNF-α alongside decreased TAC and NO contents. OT–treated animals exhibited significantly lower serum C-reactive protein, LDH and CK levels but without significant change in serum lipids. Cardiac tissue samples showed significantly lower MDA and TNF-α alongside significantly higher TAC and NO contents.

Conclusion: These results demonstrate a potent cardioprotective effect of OT hormone against hypercholesterolemia-induced cardiac injury probably via anti-inflammatory and antioxidant mechanisms.

Item Type: Article
Subjects: West Bengal Archive > Medical Science
Depositing User: Unnamed user with email support@westbengalarchive.com
Date Deposited: 15 Jun 2023 09:18
Last Modified: 03 Sep 2024 05:21
URI: http://article.stmacademicwriting.com/id/eprint/855

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