Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders

Gandhi, Tanya and Lee, Charles C. (2021) Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders. Frontiers in Cellular Neuroscience, 14. ISSN 1662-5102

[thumbnail of pubmed-zip/versions/1/package-entries/fncel-14-592710/fncel-14-592710.pdf] Text
pubmed-zip/versions/1/package-entries/fncel-14-592710/fncel-14-592710.pdf - Published Version

Download (3MB)

Abstract

Autism spectrum disorder (ASD) is comprised of several conditions characterized by alterations in social interaction, communication, and repetitive behaviors. Genetic and environmental factors contribute to the heterogeneous development of ASD behaviors. Several rodent models display ASD-like phenotypes, including repetitive behaviors. In this review article, we discuss the potential neural mechanisms involved in repetitive behaviors in rodent models of ASD and related neuropsychiatric disorders. We review signaling pathways, neural circuits, and anatomical alterations in rodent models that display robust stereotypic behaviors. Understanding the mechanisms and circuit alterations underlying repetitive behaviors in rodent models of ASD will inform translational research and provide useful insight into therapeutic strategies for the treatment of repetitive behaviors in ASD and other neuropsychiatric disorders.

Item Type: Article
Subjects: West Bengal Archive > Medical Science
Depositing User: Unnamed user with email support@westbengalarchive.com
Date Deposited: 22 May 2023 05:56
Last Modified: 16 Sep 2024 10:22
URI: http://article.stmacademicwriting.com/id/eprint/829

Actions (login required)

View Item
View Item