Comparison of liver resection and transplantation for Child-pugh A cirrhotic patient with very early hepatocellular carcinoma and portal hypertension.

Dai, Yan and LI, CHUAN and WEN, TIAN FU and YAN, LU NAN (1969) Comparison of liver resection and transplantation for Child-pugh A cirrhotic patient with very early hepatocellular carcinoma and portal hypertension. Pakistan Journal of Medical Sciences, 30 (5). ISSN 1681-715X

[thumbnail of 5038-25797-1-PB.pdf] Text
5038-25797-1-PB.pdf - Published Version

Download (812kB)

Abstract

Objective: The aim of this study was to compare the outcomes of liver transplantation and resection for very early hepatocellular carcinoma (HCC, ≤ 2 cm) patients with Child-pugh A liver function and portal hypertension.

Methods: From 2008 to 2013, 38 patients with Child-pugh class A liver function and portal hypertension were diagnosed as very early HCC, of whom 13 patients who received liver transplantation and 25 patients underwent liver resection. We compared the preoperative characteristics, recurrence-free survival (RFS) and overall survival (OS) rates of two group.

Results: The baseline characteristics of two groups were similar. No perioperative mortality and liver failure were observed in both groups. The 1-, 3- and 5-year RFS rates of patients received liver resection and liver transplantation were 92.3%, 92.3% 92.3% and 92.0%, 71.7% and 64.5% respectively (P=0.140). The 1-, 3- and 5-year OS rates of two groups were also similar (100%, 91.7% and 91.7% for group T versus 100%, 93.3% and 93.3% for group R, P=0.695).

Conclusion: Liver resection can offer satisfactory outcomes for very early HCC patients with well liver function and portal hypertension and should be considered as the first line choice for selected patients.

Abbreviations:alpha-fetoprotein (AFP), hepatocellular carcinoma (HCC), microvascular invasion (MVI) neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), total bilirubin (TB).

Item Type: Article
Subjects: West Bengal Archive > Medical Science
Depositing User: Unnamed user with email support@westbengalarchive.com
Date Deposited: 11 May 2023 07:35
Last Modified: 26 Jul 2024 07:04
URI: http://article.stmacademicwriting.com/id/eprint/768

Actions (login required)

View Item
View Item