Drug induced hepatitis among Iranian patients suffering from tuberculosis

Objectives: To identify the risk factors of anti TB drug induced hepatitis (ATDH) among the patients with tuberculosis.
Methodology: In a retrospective study, medical records of 3960 notified tuberculosis cases over the five year period (2004-2008) in Khuzestan province Health Center, south west of Iran, were reviewed and ATDH data were analyzed. Inclusion criteria were documented TB, diagnosed based on National Tuberculosis Program (NTP). Data of ATDH and non ATDH were analyzed in SPSS 16 system and by chi square and exact fisher tests.
Results: One hundred ninety eight cases including 65(32.8%) female and 133(67.2%) male with mean age of 43.2 year and SD of 9.5 were registered as ATDH during treatment and follow up period. Differences between HIV infection and intravenous drug injection in ATDH cases and non ATDH patients was statistically significant {(p=0.0001, OR: 14.2), (p=0.0001, OR: 7.5) and (p=0.0001, OR: 11.3) respectively}.
Conclusion: Among previously established risk factors for ATDH, HCV infection, IVDU and HIV infection had the most importance.