Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing

von Düring, Felicia and Ristow, Inka and Li, Meng and Denzel, Dominik and Colic, Lejla and Demenescu, Liliana Ramona and Li, Shijia and Borchardt, Viola and Liebe, Thomas and Vogel, Matthias and Walter, Martin (2019) Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing. Frontiers in Behavioral Neuroscience, 13. ISSN 1662-5153

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Abstract

Background: Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigated whether glutamate concentration in the dACC modulates brain response during salience processing.

Methods: Twenty-seven healthy subjects (12♀, 15♁) provided both STEAM MRS at 7T measuring glutamate concentrations in the dACC as well as a functional magnetic resonance imaging (fMRI) task to study the influence on content-related salience processing and expectedness. Salience was modulated for both sexual and non-sexual emotional photos in either expected or unexpected situations. Correlation between MRS and task fMRI was investigated by performing regression analyses controlling for age, gender, and gray matter partial volume.

Results/Conclusion: During picture processing, the extent of deactivation in the Posterior Cingulate Cortex (PCC) was attenuated by two different salience attributions: sexual content and unexpectedness of emotional content. Our results indicate that stimulus inherent salience induces an attenuation of the deactivation in PCC, which is in turn balanced by higher level of glutamate in the dACC.

Item Type: Article
Subjects: West Bengal Archive > Biological Science
Depositing User: Unnamed user with email support@westbengalarchive.com
Date Deposited: 24 Jan 2023 07:35
Last Modified: 14 Jun 2024 07:59
URI: http://article.stmacademicwriting.com/id/eprint/50

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