Changes in activity of free radical processes in tissues of timorous and contralateral ovaries under the effect of neoadjuvant chemotherapy

Ovarian cancer is still among the most actual unsolved problems in oncogynecological practice. We studied the effect of neoadjuvant polychemotherapy on parameters of free radical processes in tissues of tumorous and contralateral (non-tumorous) ovaries. Morphologically healthy tissues of contralateral ovaries had signs of the imbalance in antioxidant factors similar to those in the ovaries affected by tumor. Neoadjuvant polychemotherapy resulted in normalization of metabolism parameters in both tumorous and contralateral ovaries.