Gut microbial signature and gut-lung axis: A possible role in the therapy of COVID-19

Gut microbial signature and gut-lung axis: A possible role in the therapy of COVID-19 Ata Mahmoodpoor Anesthesiology and Critical Care Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran http://orcid.org/0000-0002-4361-6230 Ali Shamekh Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Sarvin Sanaie Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran http://orcid.org/0000-0003-2325-5631

The impact of gut as the origin of different disorders has led to the "gut-origin concept" of diseases. The gut microbiome regulates host defenses against viral infections, thus dysbiosis can play a major role in triggering the cascade of inflammation and causing immune imbalances in COVID-19 patients. It appears that gut microbial signature in COVID-19 patients can be used as a potential diagnostic, therapeutic, and even a prognostic marker. Personalized nutrition therapy can be used by profiling the gut microbiota of individual patients and specialized probiotics/synbiotics to modify gut dysbiosis. Hence, improving overall immune responses can be recommended in these patients.
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