The Role of Magnetic Resonance Imaging and Molecular Features in the Diagnosis of Breast Cancer

Aims: To study the importance of differential diagnosis of breast cancer using Magnetic resonance mammography.

Study Design: Cohort Study.

Place and Duration of Study: The study was conducted Republican Specialized Scientific-Practical Medical Center of Oncology and Radiology between 2017 and 2019.

Methodology: The study included a clinical and instrumental examination of 70 women with suspected breast cancer. The age of the patients was 26-75 years (average age - 49.0 ± 2 years). All patients underwent core biopsy. The procedure was performed in a horizontal position of the patient, a needle was brought in and a “shot” was performed, during which a tissue sample was taken from the focus of interest. In 5 (7.1%) cases, the second stage of verification of the diagnosis was carried out through sectoral resection with an urgent histological examination. The resulting material is sent for cytological and histological studies.

Results: The sensitivity of x-ray mammography in detecting breast tumors was 83.4%, specificity 60.0%. The sensitivity of ultrasound in the diagnosis of breast cancer was 86.4%, specificity - 44.8%. In our observations of breast MRI, the sensitivity was 97.5%, specificity 87.2%. Magnetic resonance mammography is considered a more effective method in the early diagnosis of breast cancer.

Conclusion: Breast MRI is highly sensitive, specific and accurate in assessing the prevalence and differential diagnosis between a benign and malignant process.