R46K /R125K Mutation of PKP2 Instigates H9c2 Cell Hypertrophy

Onwuli, Donatus Onukwufor and Beltran-Alvarez, Pedro, (2019) R46K /R125K Mutation of PKP2 Instigates H9c2 Cell Hypertrophy. Asian Journal of Research in Cardiovascular Diseases, 1 (1). pp. 1-7.

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Abstract

Plakophilin 2, an armadillo protein, is a constituent of the desmosomal protein complex. Its function is very important in the maintenance of the integrity of tissues exposed to mechanical stress, such as the cardiac tissues. Mutations in the PKP2 gene complex has been implicated in the development of (Arrhythmogenic Cardiomyopathy (ACM), a condition that predisposes athletes to sudden cardiac death, occurring mostly during sporting activities. In this study, we examined the effect of R46K-R125K mutations on the cardiac cells using H9c2 cells. Results show that H9c2 cells bearing mutant (R46K-R125K) gene for PKP2 develop cell hypertrophy after 24 hours, although the mechanisms inducing hypertrophy is currently unknown. However, R46 and R125 are known hotspots for arginine methylation, the authors propose that hypertrophy induction may be associated with factors related to defects in arginine methylation at these sites.

Item Type: Article
Subjects: West Bengal Archive > Medical Science
Depositing User: Unnamed user with email support@westbengalarchive.com
Date Deposited: 27 Jun 2023 06:19
Last Modified: 08 Jun 2024 08:52
URI: http://article.stmacademicwriting.com/id/eprint/1162

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